Bayesian models in computational anatomy, neurodegenerative illnesses and Brain Clouds

I will review several statistical estimation problems which arise in the computational anatomy setting, casting three problems of statistical estimation as examples of parameter estimation in the context of many templates: (i) disease estimation, (ii) segmentation and (iii) template estimation. Then I will discuss one of the central questions in neurodegenerative diseases today, the staging of neurodegeneration in brain circuits associated to the network hypothesis. I will show results from Alzeimer’s and Huntington’s disease. Along the way I will discuss progress with Susumu Mori on building several Brain Clouds associated to young subjects and aging subjects.